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Camk2d Gene Detail
 Symbol
Name
ID
Camk2d
calcium/calmodulin-dependent protein kinase II, delta
MGI:1341265


Nomenclature History
Synonyms 2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852
Genetic Map
Chromosome 3
Syntenic
 
Mapping data( 2)
Sequence Map
Chr3:126299220-126547831 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: calcium/calmodulin-dependent protein kinase II
TreeFam: TF315229
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023550 VEGA Gene Model | MGI Sequence Detail 248612 C57BL/6J ± Kb
transcript NM_001025439 RefSeq | MGI Sequence Detail 4299 C57BL/6
polypeptide Q6PHZ2 UniProt | EBI | MGI Sequence Detail 499 Not Applicable
For the selected sequences
All sequences(62)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress.
Polymorphisms SNPs within 2kb(1940 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process calcium ion transport, cardiac muscle contraction...
Component calcium- and calmodulin-dependent protein kinase complex, cytoplasm...
Function ATP binding, calmodulin binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (14)    Tissues (9)    Images (5)
Theiler Stages: 24,28
  Assay Type Assays   Results
      RNA in situ 1   14
cDNA source data(20)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(24) cDNA(24) Antibodies(1)
Microarray probesets(3)
Other database
links
EC 2.7.11.17
Ensembl Gene Model ENSMUSG00000053819
DoTS DT.101299356, DT.101399576, DT.527906, DT.55242332, DT.87025868, DT.91445949, DT.91553373, DT.91564938, DT.94131845, DT.94278363, DT.94278406, DT.97402707
Consensus CDS Project CCDS17823.1, CCDS38624.1
DFCI TC1574289, TC1585636, TC1594366, TC1594471, TC1598626, TC1607470, TC1610253, TC1612246, TC1624641
NIA Mouse Gene Index U003824
Entrez Gene 108058
VEGA Gene Model OTTMUSG00000023550
International Mouse Knockout Project Status Camk2d
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
IPR015742 Calcium/calmodulin-dependent protein kinase II isoform
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR020636 Calcium/calmodulin-dependent protein kinase-like
Graphical View of Protein Domain Structure
References
(Earliest) J:73501 Bauch A et al., "Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta." Eur J Immunol 1998 Jul;28(7):2167-77
(Latest) J:149675 Ling H et al., "Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice." J Clin Invest 2009 May;119(5):1230-40
All references(19)
Other
accession IDs
MGI:1923610, MGI:1924420

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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