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Pak2 Gene Detail
 Symbol
Name
ID
Pak2
p21 protein (Cdc42/Rac)-activated kinase 2
MGI:1339984

Nomenclature History
Synonyms A130002K10Rik, D16Ertd269e, PAK-2
Genetic Map
Chromosome 16
21.2 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr16:32016376-32079428 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pak2 ± 2 cM)
TreeFam: TF105351
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023944 VEGA Gene Model | MGI Sequence Detail 63053 C57BL/6J ± Kb
transcript NM_177326 RefSeq | MGI Sequence Detail 4135 C57BL/6
polypeptide Q8CIN4 UniProt | EBI | MGI Sequence Detail 524 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(1) : Gene trapped(1)
Polymorphisms SNPs within 2kb(184 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptosis, protein amino acid autophosphorylation...
Component cytoplasm, membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (1)    Results (3)    Tissues (1)
Theiler Stages: 28
  Assay Type Assays   Results
      Western blot 1   3
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(14) cDNA(13) Primer pair(1) Antibodies(1)
Microarray probesets(3)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000022781 (also overlaps 5330420P17Rik)
DoTS DT.101381799, DT.110736582, DT.536407
Consensus CDS Project CCDS28112.1
DFCI TC1574202, TC1615755, TC1617710
Entrez Gene 224105
VEGA Gene Model OTTMUSG00000023944
International Mouse Knockout Project Status Pak2
Protein
domains
InterPro ID Description
IPR000095 PAK-box/P21-Rho-binding
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR015750 Serine/threonine-protein kinase, Pak-related
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:46940 Zambrowicz BP et al., "Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells." Nature 1998 Apr 9;392(6676):608-11
(Latest) J:145963 Luo S et al., "Huntingtin promotes cell survival by preventing Pak2 cleavage." J Cell Sci 2009 Mar 15;122(Pt 6):875-85
All references(21)
Other
accession IDs 		MGI:1098647, MGI:2146488, MGI:2442429
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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