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Pak1 Gene Detail
 Symbol
Name
ID
Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
MGI:1339975

Nomenclature History
Synonyms PAK-1, Paka
Genetic Map
Chromosome 7
46.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr7:104991445-105060891 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pak1 ± 2 cM)
TreeFam: TF105351
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021135 VEGA Gene Model | MGI Sequence Detail 69447 C57BL/6J ± Kb
transcript NM_011035 RefSeq | MGI Sequence Detail 3081 C57BL/6
polypeptide O88643 UniProt | EBI | MGI Sequence Detail 545 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes 		All alleles(55) : Targeted, knock-out(1) Gene trapped(54)
Polymorphisms RFLP(2) SNPs within 2kb(313 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process dendrite development, neuromuscular junction development...
Component axon, cytoplasm...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (4)    Results (27)    Tissues (23)    Images (1)
Theiler Stages: 4,5,11,13,28
  Assay Type Assays   Results
      Western blot 1   3
      RT-PCR 1   4
      RNA in situ 1   2
      Northern blot 1   18
cDNA source data(53)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(57) Genomic(1) cDNA(53) Primer pair(2) Other(1) Antibodies(1)
Microarray probesets(4)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000030774
DoTS DT.101254544, DT.101407514, DT.489154, DT.97356346
Consensus CDS Project CCDS21464.1
UniGene 260227
DFCI TC1585025, TC1597406, TC1601087, TC1622084, TC1641535
NIA Mouse Gene Index U008421
Entrez Gene 18479
VEGA Gene Model OTTMUSG00000021135
International Mouse Knockout Project Status Pak1
Protein
domains
InterPro ID Description
IPR000095 PAK-box/P21-Rho-binding
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR015750 Serine/threonine-protein kinase, Pak-related
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:30018 Burbelo PD et al., "A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases." J Biol Chem 1995 Dec 8;270(49):29071-4
(Latest) J:145444 Allen JD et al., "P21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics." Blood 2009 Jan 5;():
All references(36)
Other
accession IDs 		MGI:1203486, MGI:2142185
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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