About   Help   FAQ
Csf1 Gene Detail
 Symbol
Name
ID
Csf1
colony stimulating factor 1 (macrophage)
MGI:1339753


Nomenclature History
Synonyms colony-stimulating factor-1, CSF-1, Csfm, M-CSF
Genetic Map
Chromosome 3
51.0 cM, cytoband F3
Detailed Genetic Map ± 1 cM
 
Mapping data( 24)

Sequence Map
Chr3:107543966-107563387 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Csf1 ± 2 cM)
Protein SuperFamily: macrophage colony-stimulating factor 1
TreeFam: TF337718
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026573 VEGA Gene Model | MGI Sequence Detail 19422 C57BL/6J ± Kb
transcript NM_007778 RefSeq | MGI Sequence Detail 4192 C57BL/6
polypeptide P07141 UniProt | EBI | MGI Sequence Detail 552 Not Applicable
For the selected sequences
All sequences(45)
Alleles
and
phenotypes
All alleles(1) : Spontaneous(1)
Homozygotes for a spontaneous mutation exhibit lack of incisors, a broad domed skull, short thick limb bones with reduced marrow cavities, impaired hearing and vision, and reduced fertility in females.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms RFLP(3) SNPs within 2kb(44 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process branching involved in mammary gland duct morphogenesis, homeostasis of number of cells within a tissue...
Component extracellular region, extracellular space...
Function cytokine activity, growth factor activity...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (12)    Results (65)    Tissues (33)    Images (1)
Theiler Stages: 13,14,15,19,21,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 2   29
      Nuclease S1 1   6
      Northern blot 9   30
cDNA source data(101)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(110) Genomic(4) cDNA(102) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000014599
DoTS DT.101312104, DT.111042454, DT.94133549, DT.94150590
Consensus CDS Project CCDS17740.1
UniGene 795
PDB 3EJJ
DFCI TC1576651, TC1593319, TC1596023
NIA Mouse Gene Index U024503
Entrez Gene 12977
VEGA Gene Model OTTMUSG00000026573
International Mouse Knockout Project Status Csf1
Protein
domains
InterPro ID Description
IPR008001 Macrophage colony stimulating factor-1
IPR009079 Four-helical cytokine-like, core
Graphical View of Protein Domain Structure
References
(Earliest) J:5149 Ruddle FH et al., "Esterase genetics in Mus musculus: expression, linkage, and polymorphism of locus Es-2." Genetics 1969 Jun;62(2):393-9
(Latest) J:152473 Qian B et al., "A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth." PLoS One 2009;4(8):e6562
All references(268)
Other
accession IDs
MGD-MRK-13034, MGD-MRK-2191, MGI:2140102, MGI:88534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory