Symbol
Name
ID
|
|
|
Synonyms
|
IKK-2, IKK-beta, IKK[b], IKK2, IKKbeta
|
|
Genetic Map
|
|
Chromosome 8
|
cytoband A3-A4
|
|
|
|
Mapping data(
3)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(60)
|
Alleles
and
phenotypes
|
All alleles(11) :
Targeted, knock-out(5)
Targeted, other(4)
Gene trapped(2)
| Homozygotes for targeted null mutations exhibit liver degeneration and die in midgestation. Conditional mutations that lack gene expression in lymphoid cells or epidermal keratinocytes exhibit B and T cell deficits and skin inflammation, respectively. |
Phenotype Images (3)
|
|
Polymorphisms
|
SNPs within 2kb(34 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (8 records)
Data Summary:
Assays (1)
Results (4)
Tissues (4)
Theiler Stages: 10,18,23,25
| |
Assay Type |
Assays |
|
Results |
| |
Northern blot |
1 |
|
4 |
cDNA source data(108)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(112)
cDNA(112)
Microarray probesets(3)
|
Other database
links
|
| EC |
2.7.11.10 |
| Ensembl Gene Model |
ENSMUSG00000031537 |
| DoTS |
DT.101200942, DT.101373632, DT.482112, DT.487759, DT.55174791, DT.55232479, DT.94186387, DT.94188736, DT.99860594 |
| UniGene |
277886 |
| DFCI |
TC1574554, TC1591753, TC1625530, TC1634947 |
| NIA Mouse Gene Index |
U029639 |
| Entrez Gene |
16150 |
| VEGA Gene Model |
OTTMUSG00000020581 |
| International Mouse Knockout Project Status |
Ikbkb |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:54118
Verma IM et al.,
"Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation."
Genes Dev 1995 Nov 15;9(22):2723-35
(Latest)
J:154059
Bockhart V et al.,
"Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity."
J Neurosci 2009 Oct 14;29(41):12919-29
|
All references(96)
|
Other
accession IDs
|
MGI:2142466
|
