Symbol
Name
ID
|
|
|
Synonyms
|
BCL-10, cE10, mE10
|
|
Genetic Map
|
|
Chromosome 3
|
cytoband H3
|
|
|
|
Mapping data(
3)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(40)
|
Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(2)
Gene trapped(4)
| About one-third of homozygous null embryos die exhibiting exencephaly. Surviving mutants display immunological defects including severe immunodeficiency, abnormal B cell development and function, and impaired humoral response to bacterial infection. |
|
|
Polymorphisms
|
SNPs within 2kb(13 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (2 records)
Data Summary:
Assays (2)
Results (12)
Tissues (12)
Images (2)
Theiler Stages: 10,18,23,25,28
| |
Assay Type |
Assays |
|
Results |
| |
Northern blot |
2 |
|
12 |
cDNA source data(20)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(20)
cDNA(20)
Microarray probesets(4)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:52071
Willis TG et al.,
"Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types."
Cell 1999 Jan 8;96(1):35-45
(Latest)
J:149557
Derudder E et al.,
"Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals."
Nat Immunol 2009 Jun;10(6):647-54
|
All references(39)
|
Other
accession IDs
|
MGI:2139636, MGI:2140085
|
