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Lcp2 Gene Detail
 Symbol
Name
ID
Lcp2
lymphocyte cytosolic protein 2
MGI:1321402

Nomenclature History
Synonyms SLP-76, SLP76, twm
Genetic Map
Chromosome 11
Syntenic
 
Mapping data( 2)
Sequence Map
Chr11:33946920-33992295 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF326567
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005404 VEGA Gene Model | MGI Sequence Detail 45376 C57BL/6J ± Kb
transcript NM_010696 RefSeq | MGI Sequence Detail 3348 C57BL/6
polypeptide Q60787 UniProt | EBI | MGI Sequence Detail 533 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes 		All alleles(10) : Targeted, knock-out(3) Targeted, other(6) Chemically induced(1)
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
Polymorphisms SNPs within 2kb(120 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cytokine secretion, mast cell activation...
Component cytoplasm
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(35)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(38) cDNA(38)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000002699
DoTS DT.490269, DT.91551537
UniGene 265350
PDB 1OEB, 2ETZ, 2EU0
DFCI TC1576580, TC1592180, TC1595244
NIA Mouse Gene Index U012450
Entrez Gene 16822
VEGA Gene Model OTTMUSG00000005404
International Mouse Knockout Project Status Lcp2
Protein
domains
InterPro ID Description
IPR000980 SH2 motif
IPR001660 Sterile alpha motif
IPR010993 Sterile alpha motif homology
IPR011510 Sterile alpha motif, type 2
Graphical View of Protein Domain Structure
References
(Earliest) J:24168 Jackman JK et al., "Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells." J Biol Chem 1995 Mar 31;270(13):7029-32
(Latest) J:153901 Baker RG et al., "The adapter protein SLP-76 mediates 'outside-in' integrin signaling and function in T cells." Mol Cell Biol 2009 Oct;29(20):5578-89
All references(49)
Other
accession IDs 		MGI:2144122, MGI:2144608, MGI:3584401
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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