Symbol
Name
ID
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Synonyms
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KQT2, Nmf134
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(98)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(4)
Chemically induced(1)
| Mice homozygous for a null mutation die perinatally with pulmonary atelectasis, in the absence of brain abnormalities, signs of seizures or other behavioral manifestations. Heterozygous mice appear behaviorally normal but exhibit a hypersensitivity to the epileptic inducer pentylenetetrazole. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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PCR(1)
SNPs within 2kb(396 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (5 records)
Data Summary:
Assays (6)
Results (86)
Tissues (47)
Theiler Stages: 19,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
4 |
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47 |
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In situ reporter (knock in) |
1 |
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36 |
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Northern blot |
1 |
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3 |
cDNA source data(26)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(39)
Genomic(8)
cDNA(26)
Primer pair(4)
Other(1)
Microarray probesets(8)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000016346 |
| DoTS |
DT.101145883, DT.101357587, DT.110746438, DT.110746439, DT.110746452, DT.110746458, DT.523843, DT.527011, DT.87037845, DT.87040536, DT.87048659, DT.87048660, DT.87049021, DT.91429000, DT.94313963, DT.94397896, DT.97408555 |
| DFCI |
TC1579104, TC1580722, TC1595993, TC1596531, TC1596747, TC1604003, TC1618741, TC1625841, TC1682679, TC1692735 |
| NIA Mouse Gene Index |
U023774 |
| Entrez Gene |
16536 |
| VEGA Gene Model |
OTTMUSG00000016558 |
| International Mouse Knockout Project Status |
Kcnq2 |
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Protein
domains
|
| InterPro ID |
Description |
| IPR003091 |
Voltage-dependent potassium channel |
| IPR003937 |
Potassium channel, voltage dependent, KCNQ |
| IPR003947 |
Potassium channel, voltage dependent, KCNQ2 |
| IPR005821 |
Ion transport |
| IPR013821 |
Potassium channel, voltage dependent, KCNQ, C-terminal |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:49031
Nakamura M et al.,
"KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels."
Receptors Channels 1998;5(5):255-71
(Latest)
J:142688
Tzingounis AV et al.,
"Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents."
Proc Natl Acad Sci U S A 2008 Dec 16;105(50):19974-9
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All references(15)
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Other
accession IDs
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MGI:2661794
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