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Axin2 Gene Detail
 Symbol
Name
ID
Axin2
axin2
MGI:1270862


Nomenclature History
Synonyms Axil, Conductin
Genetic Map
Chromosome 11
70.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr11:108781663-108812097 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Axin2 ± 2 cM)
Protein SuperFamily: axis inhibition protein (axin)
TreeFam: TF315454
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003199 VEGA Gene Model | MGI Sequence Detail 30435 C57BL/6J ± Kb
transcript NM_015732 RefSeq | MGI Sequence Detail 4279 C57BL/6
polypeptide O88566 UniProt | EBI | MGI Sequence Detail 840 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(2) : Targeted, other(1) Gene trapped(1)
Homozygous mutant mice exhibit premature fusion of cranial sutures, enhanced expansion of oseoprogenitors, accelerated ossification, and increased osteoblast proliferation and differentiation.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(1) SNPs within 2kb(78 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process intramembranous ossification, multicellular organismal development...
Component cytoplasm, intracellular...
Function protein binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (85 records)
Data Summary: Assays (14)    Results (92)    Tissues (57)    Images (32)
Theiler Stages: 9,11,13,14,15,17,18,19,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 3   21
      In situ reporter (knock in) 3   12
      RNA in situ 8   59
cDNA source data(52)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(57) Genomic(1) cDNA(53) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000142
DoTS DT.101130941, DT.485651
Consensus CDS Project CCDS25575.1
UniGene 71710
DFCI TC1577803
NIA Mouse Gene Index U013488
Entrez Gene 12006
VEGA Gene Model OTTMUSG00000003199
International Mouse Knockout Project Status Axin2
Protein
domains
InterPro ID Description
IPR000342 Regulator of G protein signalling
IPR001158 DIX
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:47363 Behrens J et al., "Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta." Science 1998 Apr 24;280(5363):596-9
(Latest) J:155332 Fotaki V et al., "Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon." Dev Dyn 2010 Jan;239(1):284-96
All references(103)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory