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Tcf7l2 Gene Detail
 Symbol
Name
ID
Tcf7l2
transcription factor 7-like 2, T-cell specific, HMG-box
MGI:1202879

Nomenclature History
Synonyms mTcf-4B, mTcf-4E, Tcf-4, Tcf4, TCF4B, TCF4E
Genetic Map
Chromosome 19
53.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr19:55816310-56008144 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tcf7l2 ± 2 cM)
TreeFam: TF318448
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020410 VEGA Gene Model | MGI Sequence Detail 191835 C57BL/6J ± Kb
transcript NM_001142918 RefSeq | MGI Sequence Detail 4163 C57BL/6
polypeptide Q924A0 UniProt | EBI | MGI Sequence Detail 459 Not Applicable
For the selected sequences
All sequences(69)
Alleles
and
phenotypes 		All alleles(10) : Targeted, knock-out(1) Gene trapped(9)
Animals homozygous for a targeted mutation exhibit intestinal epithelia abnormalities and die shortly after birth.
Polymorphisms SNPs within 2kb(786 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process embryonic digestive tract morphogenesis, embryonic genitalia morphogenesis...
Component cytosol, nucleus...
Function beta-catenin binding, DNA binding...
External Resources: FuncBase
Expression Literature Summary: (61 records)
Data Summary: Assays (16)    Results (228)    Tissues (136)    Images (26)
Theiler Stages: 2,3,4,5,13,14,16,17,18,19,20,21,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   18
      RNA in situ 14   210
cDNA source data(79)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(89) cDNA(81) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024985
DoTS DT.101142313, DT.101357888, DT.101408432, DT.101408435, DT.110868652, DT.530294, DT.55185608, DT.87026948, DT.91412082, DT.94276508, DT.94276515
Consensus CDS Project CCDS29911.1
UniGene 139815
DFCI TC1576789, TC1589368, TC1589691, TC1590945, TC1593611, TC1623547, TC1638533, TC1768387, TC1769434, TC1773383
NIA Mouse Gene Index U019591
Entrez Gene 21416
VEGA Gene Model OTTMUSG00000020410
International Mouse Knockout Project Status Tcf7l2
Protein
domains
InterPro ID Description
IPR000910 High mobility group, HMG1/HMG2
IPR009071 High mobility group, superfamily
IPR013558 CTNNB1 binding, N-teminal
Graphical View of Protein Domain Structure
References
(Earliest) J:45934 Korinek V et al., "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse." Mol Cell Biol 1998 Mar;18(3):1248-56
(Latest) J:155182 da Silva Xavier G et al., "TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells." Diabetes 2009 Apr;58(4):894-905
All references(77)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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