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Sorl1 Gene Detail
 Symbol
Name
ID
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
MGI:1202296


Nomenclature History
Synonyms 2900010L19Rik, gp250, LR11, mSorLA
Genetic Map
Chromosome 9
cytoband B
 
Mapping data( 5)
Sequence Map
Chr9:41772803-41932380 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
TreeFam: TF324918
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000031794 VEGA Gene Model | MGI Sequence Detail 159578 C57BL/6J ± Kb
transcript NM_011436 RefSeq | MGI Sequence Detail 6938 C57BL/6
polypeptide O88307 UniProt | EBI | MGI Sequence Detail 2215 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(15) : Targeted, knock-out(2) Gene trapped(13)
Polymorphisms SNPs within 2kb(1064 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(13)
Process cholesterol metabolic process, endocytosis...
Component integral to membrane, low-density lipoprotein particle...
Function receptor activity
External Resources: MouseFunc
Expression Literature Summary: (8 records)
Data Summary: Assays (1)    Results (6)    Tissues (3)
Theiler Stages: 24,26
  Assay Type Assays   Results
      RNA in situ 1   6
cDNA source data(121)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(124) Genomic(2) cDNA(121) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049313
DoTS DT.482918, DT.97386360
UniGene 121920
DFCI TC1601394
NIA Mouse Gene Index U030748
Entrez Gene 20660
VEGA Gene Model OTTMUSG00000031794
International Mouse Knockout Project Status Sorl1
Protein
domains
InterPro ID Description
IPR000033 Low-density lipoprotein receptor, class B (YWTD) repeat
IPR002172 Low density lipoprotein-receptor, class A (cysteine-rich) repeat
IPR003961 Fibronectin, type III
IPR006581 VPS10
IPR008957 Fibronectin, type III-like fold
IPR011042 Six-bladed beta-propeller, TolB-like
IPR013032 EGF-like region, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:46143 Hermans-Borgmeyer I et al., "Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex." Mech Dev 1998 Jan;70(1-2):65-76
(Latest) J:150768 Okado H et al., "The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex." Dev Biol 2009 Jul 15;331(2):140-51
All references(25)
Other
accession IDs
MGI:1920160, MGI:2143102, MGI:2143305

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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