Symbol
Name
ID
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Synonyms
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CIS3, Cish3, cytokine-inducible SH2 protein 3, E2a-Pbx1 target gene in fibroblasts 10, EF-10, SOCS-3, SSI-3, STAT-induced STAT inhibitor 3
|
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Genetic Map
|
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Chromosome 11
|
cytoband E2
|
|
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Mapping data(
2)
|
|
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Sequence Map
|
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Mammalian
homology
|
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Sequences
|
All sequences(31)
|
Alleles
and
phenotypes
|
All alleles(15) :
Targeted, knock-out(3)
Targeted, other(4)
Gene trapped(8)
| Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality. |
|
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Polymorphisms
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SNPs within 2kb(1 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (6 records)
Data Summary:
Assays (2)
Results (12)
Tissues (12)
Theiler Stages: 10,18,23,25,28
| |
Assay Type |
Assays |
|
Results |
| |
Northern blot |
2 |
|
12 |
cDNA source data(51)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(51)
cDNA(51)
Microarray probesets(3)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:42258
Minamoto S et al.,
"Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
Biochem Biophys Res Commun 1997 Aug 8;237(1):79-83
(Latest)
J:153361
Taleb S et al.,
"Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis."
J Exp Med 2009 Sep 28;206(10):2067-77
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All references(88)
|
