Symbol
Name
ID
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Synonyms
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CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(35)
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Alleles
and
phenotypes
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All alleles(15) :
Targeted, other(1)
Gene trapped(13)
Spontaneous(1)
| Mutations in this gene cause accelerated postnatal growth. Homozygotes for a targeted mutation also show increased bone growth, enlargement of most organs, collagen deposition in the skin and some ducts and vessels, lower major urinary protein levels, and elevated IGF-I mRNA levels in some tissues. |
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Polymorphisms
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SNPs within 2kb(99 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (4 records)
Data Summary:
Assays (1)
Results (20)
Tissues (10)
Theiler Stages: 18,21,23,25,28
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Assay Type |
Assays |
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Results |
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Northern blot |
1 |
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20 |
cDNA source data(14)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(16)
cDNA(16)
Microarray probesets(3)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:7780
Bradford GE et al.,
"Evidence for a major gene for rapid postweaning growth in mice."
Genet Res 1984 Dec;44(3):293-308
(Latest)
J:148540
Farber CR et al.,
"Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling."
Physiol Genomics 2009 May 13;37(3):294-302
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All references(60)
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Other
accession IDs
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MGD-MRK-10702, MGI:2143636, MGI:2143807, MGI:96077
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