Symbol
Name
ID
|
Cacna1g
calcium channel, voltage-dependent, T type, alpha 1G subunit
MGI:1201678
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Nomenclature History
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Synonyms
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a1G, Cav3.1d, mKIAA1123
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Genetic Map
|
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Chromosome 11
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Syntenic
|
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Mapping data(
1)
|
|
|
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Sequence Map
|
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Mammalian
homology
|
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Sequences
|
All sequences(35)
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Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(4)
Targeted, other(2)
| Homozygote null mice display disrupted sleeping patterns, altered amounts of activity, abnormal action potentials in the brain, prolonged electrical conductance in the heart, and resistance to diet-induced obesity. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(300 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (10 records)
Data Summary:
Assays (5)
Results (24)
Tissues (15)
Images (1)
Theiler Stages: 15,20,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
5 |
|
24 |
cDNA source data(57)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(62)
cDNA(57)
Primer pair(4)
Other(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR002077 |
Voltage-dependent calcium channel, alpha-1 subunit |
| IPR005445 |
Voltage-dependent calcium channel, T-type, alpha-1 subunit |
| IPR005821 |
Ion transport |
|
|
References
|
(Earliest)
J:46135
Perez-Reyes E et al.,
"Molecular characterization of a neuronal low-voltage-activated T-type calcium channel [see comments]"
Nature 1998 Feb 26;391(6670):896-900
(Latest)
J:155560
Nakayama H et al.,
"alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice."
J Clin Invest 2009 Dec;119(12):3787-96
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All references(27)
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Analysis Tools
MGI BioMart