Symbol
Name
ID
|
|
|
Synonyms
|
Madh3, Smad 3
|
|
Genetic Map
|
|
Chromosome 9
|
cytoband D
|
|
|
|
Mapping data(
4)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(31)
|
Alleles
and
phenotypes
|
All alleles(8) :
Targeted, knock-out(3)
Targeted, other(2)
Gene trapped(3)
| Homozygotes for targeted mutations exhibit reduced mucosal immunity, chronic intestinal inflammation (sometimes with colonic adenocarcinoma), forelimb malformation, reduced mineralization of enamel, impaired growth of ovarian follicles, and develop osteoarthritis. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
Phenotype Images (3)
|
|
Polymorphisms
|
SNPs within 2kb(438 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (41 records)
Data Summary:
Assays (12)
Results (68)
Tissues (42)
Images (9)
Theiler Stages: 2,3,4,5,7,8,10,14,20,21,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
6 |
| |
RT-PCR |
7 |
|
36 |
| |
RNA in situ |
3 |
|
20 |
| |
Northern blot |
1 |
|
6 |
cDNA source data(111)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(126)
Genomic(4)
cDNA(113)
Primer pair(8)
Other(1)
Antibodies(2)
Microarray probesets(3)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:46375
Zhao J et al.,
"Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture."
Dev Biol 1998 Feb 15;194(2):182-95
(Latest)
J:156253
Tateossian H et al.,
"Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant."
Pathogenetics 2009;2(1):5
|
All references(187)
|
Other
accession IDs
|
MGI:2143216
|
Analysis Tools
MGI BioMart