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Wnt9b Gene Detail
 Symbol
Name
ID
Wnt9b
wingless-type MMTV integration site 9B
MGI:1197020


Nomenclature History
Synonyms clf, clf1, Wnt14b, Wnt15
Genetic Map
Chromosome 11
63.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr11:103588678-103611135 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt9b ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000003017 VEGA Gene Model | MGI Sequence Detail 22458 C57BL/6J ± Kb
transcript NM_011719 RefSeq | MGI Sequence Detail 4519 C57BL/6
polypeptide O35468 UniProt | EBI | MGI Sequence Detail 359 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Spontaneous(1)
Homozygous null mice display neonatal lethality, disrupted ureteric bud branching, impaired Mullerian duct formation, and incompletely penetrant cleft lip and palate. In mice with alleles that decrease expression kidneys are smaller with fewer mature nephrons.
Phenotype Images (1)  
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(132 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell-cell signaling, multicellular organismal development...
Component extracellular region, proteinaceous extracellular matrix...
Function receptor binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (34 records)
Data Summary: Assays (10)    Results (152)    Tissues (133)    Images (20)
Theiler Stages: 1,2,3,4,5,8,9,10,11,13,15,17,18,19,20,21,22,23,25,26,28
  Assay Type Assays   Results
      RT-PCR 5   43
      RNA in situ 4   107
      RNase protection 1   2
cDNA source data(12)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(30) Genomic(6) cDNA(12) Primer pair(9) Other(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000018486
DoTS DT.87057942
Consensus CDS Project CCDS25522.1
UniGene 215161
DFCI TC1588043, TC1642958
Entrez Gene 22412
VEGA Gene Model OTTMUSG00000003017
International Mouse Knockout Project Status Wnt9b
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:8487 Biddle FG et al., "Major gene determination of liability to spontaneous cleft lip in the mouse." J Craniofac Genet Dev Biol Suppl 1986;2():67-88
(Latest) J:154102 Cain JE et al., "GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells." PLoS One 2009;4(10):e7313
All references(57)
Other
accession IDs
MGD-MRK-16443, MGD-MRK-2011, MGI:99658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory