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Fzd1 Gene Detail
 Symbol
Name
ID
Fzd1
frizzled homolog 1 (Drosophila)
MGI:1196625

Nomenclature History
Synonyms FZ-1
Genetic Map
Chromosome 5
5.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr5:4753873-4758035 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd1 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021313 VEGA Gene Model | MGI Sequence Detail 4163 C57BL/6J ± Kb
transcript NM_021457 RefSeq | MGI Sequence Detail 4395 C57BL/6
polypeptide O70421 UniProt | EBI | MGI Sequence Detail 642 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes 		All alleles(1) : Targeted, other(1)
Homozygous mutation of this gene does not appear to result in a phenotype.
Polymorphisms SNPs within 2kb(24 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell surface receptor linked signal transduction, cell-cell signaling...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (27 records)
Data Summary: Assays (11)    Results (309)    Tissues (222)    Images (124)
Theiler Stages: 1,2,3,4,5,19,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 5   61
      In situ reporter (knock in) 1   129
      RNA in situ 4   113
      Immunohistochemistry 1   6
cDNA source data(71)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(81) cDNA(72) Primer pair(8) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000044674
DoTS DT.526604
Consensus CDS Project CCDS19072.1
UniGene 246003
DFCI TC1576237, TC1691698
NIA Mouse Gene Index U005275
Entrez Gene 14362
VEGA Gene Model OTTMUSG00000021313
International Mouse Knockout Project Status Fzd1
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:45301 Cygan JA et al., "Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants." Development 1997 Dec;124(24):5021-32
(Latest) J:152099 Bi Y et al., "Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells." J Cell Biochem 2009 Jun 26;108(1):295-303
All references(33)
Other
accession IDs 		MGI:2141181
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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