About   Help   FAQ
Tour our new Quick Search
Kcnj10 Gene Detail
 Symbol
Name
ID
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
MGI:1194504

Nomenclature History
STS 416F4T7
Synonyms BIR10, BIRK-1, Kir1.2, Kir4.1, Kir4.1
Genetic Map
Chromosome 1
93.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 10)

Sequence Map
Chr1:174271341-174304216 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Kcnj10 ± 2 cM)
Protein SuperFamily: G protein-activated inward rectifier potassium channel
TreeFam: TF313676
Sequences
Representative Sequences Length Strain/Species Flank
genomic 16513 NCBI Gene Model | MGI Sequence Detail 32876 C57BL/6J ± Kb
transcript NM_001039484 RefSeq | MGI Sequence Detail 5407 C57BL/6
polypeptide Q9JM63 UniProt | EBI | MGI Sequence Detail 379 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(1)
Homozygous mutant mice show increased input resistance and high depolarization of retinal Muller cells, loss of the endocochlear potential, motor coordination deficits and hindlimb paralysis, and a hypomyelination and spongiform vacuolation in the spinal cord associated with severe axonal pathology.
Polymorphisms RFLP(2) SNPs within 2kb(131 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(15)
Process ion transport, potassium ion transport...
Component integral to membrane, integral to plasma membrane...
Function ATP binding, inward rectifier potassium channel activity...
External Resources: MouseFunc
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (10)    Tissues (6)
Theiler Stages: 13,15,17,25,28
  Assay Type Assays   Results
      RT-PCR 2   10
cDNA source data(29)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(40) Genomic(9) cDNA(29) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000044708
DoTS DT.94289231, DT.97411784, DT.97411785
UniGene 254563
DFCI TC1583302, TC1598226
NIA Mouse Gene Index U001106
Entrez Gene 16513
International Mouse Knockout Project Status Kcnj10
Protein
domains
InterPro ID Description
IPR001838 Potassium channel, inwardly rectifying, Kir-like
IPR003269 Potassium channel, inwardly rectifying, Kir1.2
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
IPR013521 Potassium channel, inwardly rectifying, Kir, conserved region 2
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir
Graphical View of Protein Domain Structure
References
(Earliest) J:44256 Tada Y et al., "Assignment of the glial inwardly rectifying potassium channel KAB-2/Kir4.1 (Kcnj10) gene to the distal region of mouse chromosome 1." Genomics 1997 Nov 1;45(3):629-30
(Latest) J:134489 Trowe MO et al., "Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes." Development 2008 May;135(9):1725-34
All references(27)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory