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Pik3r2 Gene Detail
 Symbol
Name
ID
Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
MGI:1098772

Nomenclature History
Synonyms p85beta
Genetic Map
Chromosome 8
33.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr8:73292075-73300612 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pik3r2 ± 2 cM)
Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
TreeFam: TF102033
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000032469 VEGA Gene Model | MGI Sequence Detail 8538 C57BL/6J ± Kb
transcript NM_008841 RefSeq | MGI Sequence Detail 3159 C57BL/6
polypeptide O08908 UniProt | EBI | MGI Sequence Detail 722 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well.
Polymorphisms SNPs within 2kb(22 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process insulin receptor signaling pathway, negative regulation of anti-apoptosis...
Component intracellular, phosphoinositide 3-kinase complex...
Function kinase activity, phosphoinositide 3-kinase regulator activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (25)    Tissues (18)
Theiler Stages: 21,25,28
  Assay Type Assays   Results
      Northern blot 1   25
cDNA source data(7)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(7) cDNA(7)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000031834
DoTS DT.110878733, DT.489669
Consensus CDS Project CCDS22381.1
DFCI TC1577167
NIA Mouse Gene Index U029930
Entrez Gene 18709
VEGA Gene Model OTTMUSG00000032469
International Mouse Knockout Project Status Pik3r2
Protein
domains
InterPro ID Description
IPR000198 RhoGAP
IPR000980 SH2 motif
IPR001452 Src homology-3 domain
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
Graphical View of Protein Domain Structure
References
(Earliest) J:36742 Pons S et al., "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase." Mol Cell Biol 1995 Aug;15(8):4453-65
(Latest) J:148122 Alcazar I et al., "p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function." Blood 2009 Apr 2;113(14):3198-208
All references(30)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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