Symbol
Name
ID
|
|
|
Synonyms
|
CBP, KAT3A
|
|
Genetic Map
|
|
Chromosome 16
|
Syntenic
|
|
|
|
Mapping data(
2)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(33)
|
Alleles
and
phenotypes
|
All alleles(27) :
Targeted, knock-out(4)
Targeted, other(6)
Gene trapped(17)
| Homozygotes for null or altered alleles die around midgestation with defects in hemopoiesis, blood vessel formation, and neural tube closure. Heterozygotes may exhibit skeletal, cardiac, and hematopoietic defects, retarded growth, and hematologic tumors. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (3)
Phenotype Images (2)
|
|
Polymorphisms
|
SNPs within 2kb(243 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (22 records)
Data Summary:
Assays (5)
Results (23)
Tissues (23)
Images (3)
Theiler Stages: 5,12,17,18,19,21
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
4 |
| |
RT-PCR |
1 |
|
1 |
| |
RNA in situ |
3 |
|
18 |
cDNA source data(15)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(18)
Genomic(1)
cDNA(15)
Primer pair(1)
Other(1)
Antibodies(1)
Microarray probesets(3)
|
Other database
links
|
| EC |
2.3.1.48 |
| Ensembl Gene Model |
ENSMUSG00000022521, ENSMUSG00000075417 |
| DoTS |
DT.103585853, DT.94131253 |
| Consensus CDS Project |
CCDS27915.1 |
| PDB |
1F81, 1JJS, 1KBH, 1KDX, 1L8C, 1R8U, 1SB0, 1TOT, 1U2N, 2AGH, 2C52, 2KA4, 2KA6 |
| DFCI |
TC1597060, TC1636155 |
| NIA Mouse Gene Index |
U036730, U036732 |
| Entrez Gene |
12914 |
| International Mouse Knockout Project Status |
Crebbp |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000197 |
Zinc finger, TAZ-type |
| IPR000433 |
Zinc finger, ZZ-type |
| IPR001487 |
Bromodomain |
| IPR003101 |
Coactivator CBP, KIX |
| IPR009110 |
Nuclear receptor coactivator, interlocking |
| IPR010303 |
Protein of unknown function DUF902, CREBbp |
| IPR013178 |
Histone 3, Lys-56 acetylation protein, RTT109 |
| IPR014744 |
Nuclear receptor coactivator, CREB-bp-like, interlocking |
| IPR018359 |
Bromodomain, conserved site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:34578
Chrivia JC et al.,
"Phosphorylated CREB binds specifically to the nuclear protein CBP."
Nature 1993 Oct 28;365(6449):855-9
(Latest)
J:155468
Kimbrel EA et al.,
"Systematic in vivo structure-function analysis of p300 in hematopoiesis."
Blood 2009 Nov 26;114(23):4804-12
|
All references(96)
|
Other
accession IDs
|
MGI:2146668
|
|
Analysis Tools
MGI BioMart