Symbol
Name
ID
|
|
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Synonyms
|
Ifnar-2
|
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Genetic Map
|
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(52)
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Alleles
and
phenotypes
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All alleles(13) :
Targeted, knock-out(3)
Gene trapped(9)
Chemically induced(1)
| Mice with mutations of this gene have defects in immune responses involving, variously, NK cells, CD4+ and CD8+ T cells and B cells in response to induced and transplanted tumors, viruses, and double stranded DNA. These defects include diminished secretion of type I and type II interferons. |
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Polymorphisms
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SNPs within 2kb(76 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (5 records)
Data Summary:
Assays (7)
Results (114)
Tissues (85)
Images (3)
Theiler Stages: 13,15,16,17,20,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
2 |
| |
RT-PCR |
2 |
|
18 |
| |
RNA in situ |
2 |
|
48 |
| |
Northern blot |
2 |
|
46 |
cDNA source data(71)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(73)
cDNA(71)
Primer pair(2)
Antibodies(1)
Microarray probesets(3)
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Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001187 |
Tissue factor |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR015373 |
Interferon alpha/beta receptor, beta chain |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:40624
Beebe AM et al.,
"Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice."
Immunity 1997 May;6(5):551-7
(Latest)
J:147136
Kumagai Y et al.,
"Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells."
J Immunol 2009 Apr 1;182(7):3960-4
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All references(33)
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Other
accession IDs
|
MGI:2146482
|
Analysis Tools
MGI BioMart
