Symbol
Name
ID
|
|
|
Synonyms
|
2410099E07Rik, 2610208K16Rik, p110delta
|
|
Genetic Map
|
|
Chromosome 4
|
Syntenic
|
|
|
|
Mapping data(
2)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(62)
|
Alleles
and
phenotypes
|
All alleles(11) :
Targeted, knock-out(2)
Targeted, other(2)
Gene trapped(7)
| Homozygotes for targeted null mutations exhibit impaired B and T cell antigen receptor signaling, reduced or ablated immune responses and decreased immunoglobulin levels. Mutants also develop inflammatory bowel disease. |
|
|
Polymorphisms
|
SNPs within 2kb(265 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (4 records)
cDNA source data(72)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(73)
Genomic(1)
cDNA(72)
Microarray probesets(4)
|
Other database
links
|
| EC |
2.7.1.153 |
| Ensembl Gene Model |
ENSMUSG00000039936 |
| DoTS |
DT.101304999, DT.101405035, DT.101405040, DT.110834576, DT.91375213, DT.94166534, DT.94166538, DT.99864449, DT.99864456 |
| UniGene |
229108 |
| DFCI |
TC1572569, TC1606478, TC1678150, TC1683893 |
| NIA Mouse Gene Index |
U025808 |
| Entrez Gene |
18707 |
| VEGA Gene Model |
OTTMUSG00000010264 |
| International Mouse Knockout Project Status |
Pik3cd |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000341 |
Phosphoinositide 3-kinase, ras-binding |
| IPR000403 |
Phosphatidylinositol 3-/4-kinase, catalytic |
| IPR001263 |
Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR002420 |
Phosphoinositide 3-kinase, C2 |
| IPR003113 |
Phosphatidylinositol 3-kinase, p85-binding |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR011009 |
Protein kinase-like domain |
| IPR015433 |
Phosphatidylinositol Kinase |
| IPR016024 |
Armadillo-type fold |
| IPR018936 |
Phosphatidylinositol 3- and 4-kinase, conserved site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:42042
Chantry D et al.,
"p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes."
J Biol Chem 1997 Aug 1;272(31):19236-41
(Latest)
J:151583
Liu D et al.,
"The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells."
J Immunol 2009 Aug 1;183(3):1921-33
|
All references(57)
|
Other
accession IDs
|
MGI:1917688, MGI:1925744, MGI:2140589
|
