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Cyp4a14 Gene Detail
 Symbol
Name
ID
Cyp4a14
cytochrome P450, family 4, subfamily a, polypeptide 14
MGI:1096550


Nomenclature History
Genetic Map
Chromosome 4
49.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr4:115158805-115168747 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
rat    (Mammalian Orthology)
Protein SuperFamily: cytochrome P450 CYP4B1
TreeFam: TF105088
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000008625 VEGA Gene Model | MGI Sequence Detail 9943 C57BL/6J ± Kb
transcript NM_007822 RefSeq | MGI Sequence Detail 2503 C57BL/6
polypeptide O35728 UniProt | EBI | MGI Sequence Detail 507 Not Applicable
For the selected sequences
All sequences(25)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Male mice homozygous for disruption of this gene display high blood pressure. Blood pressure is elevated in females as well to levels comparable to normotensive males.
Polymorphisms SNPs within 2kb(77 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process oxidation reduction
Component endoplasmic reticulum, membrane...
Function alkane 1-monooxygenase activity, electron carrier activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (12)    Tissues (12)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      RT-PCR 1   12
cDNA source data(7)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(17) Genomic(8) cDNA(7) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
EC 1.14.15.3
Ensembl Gene Model ENSMUSG00000028715
DoTS DT.492589, DT.94399004
Consensus CDS Project CCDS18491.1
DFCI TC1580874
NIA Mouse Gene Index U025396
Entrez Gene 13119
VEGA Gene Model OTTMUSG00000008625
International Mouse Knockout Project Status Cyp4a14
Protein
domains
InterPro ID Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site
IPR017973 Cytochrome P450, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:42094 Heng YM et al., "A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans." Biochem J 1997 Aug 1;325(Pt 3):741-9
(Latest) J:121394 Muller DN et al., "Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation." Biochem J 2007 Apr 1;403(1):109-18
All references(7)
Other
accession IDs
MGI:2140223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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