About   Help   FAQ
Axin1 Gene Detail
 Symbol
Name
ID
Axin1
axin 1
MGI:1096327


Nomenclature History
Genetic Map
Chromosome 17
11.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 14)

Sequence Map
Chr17:26275633-26332761 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Axin1 ± 2 cM)
Protein SuperFamily: axis inhibition protein (axin)
TreeFam: TF315454
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000026498 VEGA Gene Model | MGI Sequence Detail 57129 C57BL/6J ± Kb
transcript NM_009733 RefSeq | MGI Sequence Detail 3809 C57BL/6
polypeptide O35625 UniProt | EBI | MGI Sequence Detail 863 Not Applicable
For the selected sequences
All sequences(29)
Alleles
and
phenotypes
All alleles(16) : Targeted, other(5) Gene trapped(7) Transgenic(1) Spontaneous(3)
Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.
Polymorphisms RFLP(1) SNPs within 2kb(57 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process multicellular organismal development, negative regulation of Wnt receptor signaling pathway...
Component cytoplasm, cytoplasmic membrane-bounded vesicle...
Function protein homodimerization activity, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (5)    Results (26)    Tissues (10)    Images (7)
Theiler Stages: 17,21,22,24,26,28
  Assay Type Assays   Results
      Western blot 3   14
      RNA in situ 2   12
cDNA source data(106)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(109) cDNA(108) Primer pair(1) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024182
DoTS DT.532261, DT.94403039
Consensus CDS Project CCDS28547.1
UniGene 23684
DFCI TC1597217, TC1601650
NIA Mouse Gene Index U017701
Entrez Gene 12005
VEGA Gene Model OTTMUSG00000026498
International Mouse Knockout Project Status Axin1
Protein
domains
InterPro ID Description
IPR000342 Regulator of G protein signalling
IPR001158 DIX
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:12953 Reed SC, "The Inheritance and Expression of Fused, a New Mutation in the House Mouse." Genetics 1937 Jan;22(1):1-13
(Latest) J:147293 Chia IV et al., "Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis." Genetics 2009 Apr;181(4):1359-68
All references(70)
Other
accession IDs
MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory