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Nck1 Gene Detail
 Symbol
Name
ID
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
MGI:109601

Nomenclature History
Synonyms 6330586M15Rik, D230010O13Rik, Nck
Genetic Map
Chromosome 9
Syntenic
 
Mapping data( 3)
Sequence Map
Chr9:100392712-100446472 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: adapter protein NCK
TreeFam: TF351631
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021049 VEGA Gene Model | MGI Sequence Detail 53761 C57BL/6J ± Kb
transcript NM_010878 RefSeq | MGI Sequence Detail 1699 FVB/N
polypeptide NP_035008 RefSeq | MGI Sequence Detail 377 FVB/N
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(18) : Targeted, other(1) Gene trapped(17)
Mice homozygous for disruption of this gene display no abnormal phenotype.
Polymorphisms SNPs within 2kb(232 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process actin filament organization, cell migration...
Component vesicle membrane
Function kinase activity, protein binding...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (4)    Results (57)    Tissues (31)    Images (1)
Theiler Stages: 11,13,17,28
  Assay Type Assays   Results
      Western blot 2   16
      In situ reporter (knock in) 1   33
      Northern blot 1   8
cDNA source data(49)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(52) cDNA(52) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000032475
DoTS DT.101710220, DT.529820
Consensus CDS Project CCDS23440.1
UniGene 181485
DFCI TC1578812, TC1587583
NIA Mouse Gene Index U031242
Entrez Gene 17973
VEGA Gene Model OTTMUSG00000021049
International Mouse Knockout Project Status Nck1
Protein
domains
InterPro ID Description
IPR000108 Neutrophil cytosol factor 2
IPR000980 SH2 motif
IPR001452 Src homology-3 domain
IPR017304 Cytoplasmic, NCK
IPR020473 Src homology-3, region
References
(Earliest) J:39581 Margolis B et al., "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains." Proc Natl Acad Sci U S A 1992 Oct 1;89(19):8894-8
(Latest) J:152508 Guan S et al., "Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration." J Invest Dermatol 2009 Aug;129(8):1909-20
All references(23)
Other
accession IDs 		MGD-MRK-39600, MGI:1097154, MGI:2441714, MGI:2441955
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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