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Itga8 Gene Detail
 Symbol
Name
ID
Itga8
integrin alpha 8
MGI:109442


Nomenclature History
Genetic Map
Chromosome 2
7.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 1)

Sequence Map
Chr2:12028259-12223555 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Itga8 ± 2 cM)
Protein SuperFamily: integrin alpha, VLA protein type
TreeFam: TF105391
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000011364 VEGA Gene Model | MGI Sequence Detail 195297 C57BL/6J ± Kb
transcript NM_001001309 RefSeq | MGI Sequence Detail 5782 C57BL/6
polypeptide A2ARA8 UniProt | EBI | MGI Sequence Detail 1062 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Mice homozygous for disruptions in this gene usually die by the end of the second day after birth. Those that do survive have reduced kidneys and abnormal steriocilia in the inner ear.
Polymorphisms SNPs within 2kb(900 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(21)
Process cell adhesion, cell differentiation...
Component apical part of cell, integral to membrane...
Function calcium ion binding, protein binding...
External Resources: MouseFunc
Expression Literature Summary: (14 records)
Data Summary: Assays (1)    Results (8)    Tissues (2)    Images (10)
Theiler Stages: 21
  Assay Type Assays   Results
      RNA in situ 1   8
cDNA source data(47)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(50) Genomic(2) cDNA(47) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000026768
DoTS DT.101722872, DT.526933
UniGene 329997
DFCI TC1590580, TC1665622
NIA Mouse Gene Index U040949
Entrez Gene 241226
VEGA Gene Model OTTMUSG00000011364
International Mouse Knockout Project Status Itga8
Protein
domains
InterPro ID Description
IPR000413 Integrin alpha chain
IPR013513 Integrin alpha chain, C-terminal, cytoplasmic region
IPR013517 FG-GAP
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:38838 Muller U et al., "Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis." Cell 1997 Mar 7;88(5):603-13
(Latest) J:152844 Driskell RR et al., "Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis." Development 2009 Aug;136(16):2815-23
All references(18)
Other
accession IDs
MGD-MRK-38487, MGI:2138946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory