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Irs2 Gene Detail
 Symbol
Name
ID
Irs2
insulin receptor substrate 2
MGI:109334

Nomenclature History
Synonyms Irs-2
Genetic Map
Chromosome 8
5.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr8:11004468-11008430 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Irs2 ± 2 cM)
Protein SuperFamily: insulin receptor substrate
TreeFam: TF325994
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000038894 Ensembl Gene Model | MGI Sequence Detail 3963 C57BL/6J ± Kb
transcript NM_001081212 RefSeq | MGI Sequence Detail 4015 -
polypeptide NP_001074681 RefSeq | MGI Sequence Detail 1321 -
For the selected sequences
All sequences(14)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(3) Targeted, other(3)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (3)  
Polymorphisms RFLP(1) SNPs within 2kb(47 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(8)
Process brain development, cell proliferation...
Function protein kinase binding, receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (5 records)
Data Summary: Assays (3)    Results (3)    Tissues (2)
Theiler Stages: 26,28
  Assay Type Assays   Results
      RT-PCR 3   3
cDNA source data(20)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents 		All nucleic(41) Genomic(20) cDNA(20) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000038894
DoTS DT.486942
UniGene 407207
DFCI TC1668845
NIA Mouse Gene Index U029580
Entrez Gene 384783
International Mouse Knockout Project Status Irs2
Protein
domains
InterPro ID Description
IPR001849 Pleckstrin homology
IPR002404 Insulin receptor substrate-1, PTB
IPR011993 Pleckstrin homology-type
References
(Earliest) J:38317 Sun XJ et al., "Role of IRS-2 in insulin and cytokine signalling." Nature 1995 Sep 14;377(6545):173-7
(Latest) J:152605 Guo S et al., "The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis." Mol Cell Biol 2009 Sep;29(18):5070-83
All references(78)
Other
accession IDs 		MGD-MRK-38379
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory