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Fzd5 Gene Detail
 Symbol
Name
ID
Fzd5
frizzled homolog 5 (Drosophila)
MGI:108571

Nomenclature History
Synonyms 5330434N09Rik, Fz5
Genetic Map
Chromosome 1
30.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr1:64777132-64784324 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd5 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic 14367 NCBI Gene Model | MGI Sequence Detail 7193 C57BL/6J ± Kb
transcript NM_022721 RefSeq | MGI Sequence Detail 6930 C57BL/6
polypeptide Q9EQD0 UniProt | EBI | MGI Sequence Detail 585 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(9) : Targeted, knock-out(1) Targeted, other(3) Gene trapped(5)
Mice homozygous for disruption of this gene die as embryos. Extra embryonic vascular development is abnormal.
Polymorphisms RFLP(1) SNPs within 2kb(45 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process angiogenesis, cell differentiation...
Component Golgi apparatus, integral to membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (27 records)
Data Summary: Assays (9)    Results (147)    Tissues (132)    Images (20)
Theiler Stages: 1,2,3,4,5,16,17,18,19,20,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 5   25
      RNA in situ 3   118
      Immunohistochemistry 1   4
cDNA source data(9)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(17) cDNA(10) Primer pair(6) Other(1) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000045005, ENSMUSG00000080018
DoTS DT.101735505, DT.523094
Consensus CDS Project CCDS15008.1
DFCI TC1582914, TC1584523, TC1617515
NIA Mouse Gene Index U069932
Entrez Gene 14367
International Mouse Knockout Project Status Fzd5
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y et al., "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." J Biol Chem 1996 Feb 23;271(8):4468-76
(Latest) J:152099 Bi Y et al., "Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells." J Cell Biochem 2009 Jun 26;108(1):295-303
All references(33)
Other
accession IDs 		MGD-MRK-37615, MGI:1925523, MGI:2138230
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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