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Fzd3 Gene Detail
 Symbol
Name
ID
Fzd3
frizzled homolog 3 (Drosophila)
MGI:108476

Nomenclature History
Synonyms Fz3
Genetic Map
Chromosome 14
27.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr14:65819863-65881300 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd3 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020983 VEGA Gene Model | MGI Sequence Detail 61438 C57BL/6J ± Kb
transcript NM_021458 RefSeq | MGI Sequence Detail 12742 -
polypeptide Q61086 UniProt | EBI | MGI Sequence Detail 666 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes 		All alleles(1) : Targeted, other(1)
Mice homozygous for disruption of this gene die within 30 minutes of birth. Breathing is irregular. Brain development is abnormal with occasion falure of the cephalic neural tube to close.
Polymorphisms RFLP(1) SNPs within 2kb(172 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell surface receptor linked signal transduction, establishment of planar polarity...
Component apical part of cell, integral to membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (38 records)
Data Summary: Assays (7)    Results (133)    Tissues (118)    Images (24)
Theiler Stages: 1,2,3,4,5,18,19,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 5   25
      RNA in situ 2   108
cDNA source data(8)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(17) Genomic(1) cDNA(9) Primer pair(5) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000007989
DoTS DT.102555530, DT.522566, DT.94179317
Consensus CDS Project CCDS27212.1
DFCI TC1585394, TC1644150, TC1689814
NIA Mouse Gene Index U035691
Entrez Gene 14365
VEGA Gene Model OTTMUSG00000020983
International Mouse Knockout Project Status Fzd3
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y et al., "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." J Biol Chem 1996 Feb 23;271(8):4468-76
(Latest) J:155359 Stuebner S et al., "Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect." Dev Dyn 2010 Jan;239(1):246-60
All references(46)
Other
accession IDs 		MGD-MRK-37520, MGI:2145736
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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