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Fzd6 Gene Detail
 Symbol
Name
ID
Fzd6
frizzled homolog 6 (Drosophila)
MGI:108474


Nomenclature History
Synonyms Fz6
Genetic Map
Chromosome 15
13.1 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr15:38837898-38869732 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd6 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000022297 Ensembl Gene Model | MGI Sequence Detail 31835 C57BL/6J ± Kb
transcript NM_008056 RefSeq | MGI Sequence Detail 4090 C57BL/6
polypeptide Q61089 UniProt | EBI | MGI Sequence Detail 709 Not Applicable
For the selected sequences
All sequences(25)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygous mice for one mutation display abnormal hair follicle orientation. Another mutation of this gene does not appear to result in a phenotype.
Polymorphisms RFLP(1) SNPs within 2kb(149 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process cell surface receptor linked signal transduction, establishment of planar polarity...
Component apical part of cell, apicolateral plasma membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (34 records)
Data Summary: Assays (10)    Results (265)    Tissues (183)    Images (65)
Theiler Stages: 1,2,3,4,5,15,19,20,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 6   66
      In situ reporter (knock in) 1   87
      RNA in situ 2   109
      Northern blot 1   3
cDNA source data(26)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(36) Genomic(1) cDNA(27) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022297
DoTS DT.101361092, DT.40156000, DT.55156594
UniGene 4769
DFCI TC1580206, TC1728399
NIA Mouse Gene Index U016198
Entrez Gene 14368
International Mouse Knockout Project Status Fzd6
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y et al., "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." J Biol Chem 1996 Feb 23;271(8):4468-76
(Latest) J:152099 Bi Y et al., "Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells." J Cell Biochem 2009 Jun 26;108(1):295-303
All references(42)
Other
accession IDs
MGD-MRK-37518

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory