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Sfrp2 Gene Detail
 Symbol
Name
ID
Sfrp2
secreted frizzled-related protein 2
MGI:108078

Nomenclature History
Synonyms Sdf5
Genetic Map
Chromosome 3
38.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr3:83570243-83578238 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sfrp2 ± 2 cM)
Protein SuperFamily: secreted frizzled-related protein
TreeFam: TF350133
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021261 VEGA Gene Model | MGI Sequence Detail 7996 C57BL/6J ± Kb
transcript NM_009144 RefSeq | MGI Sequence Detail 2001 -
polypeptide P97299 UniProt | EBI | MGI Sequence Detail 295 Not Applicable
For the selected sequences
All sequences(21)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(3) Targeted, other(1) Chemically induced(2)
Mice homozygous for a null allele exhibit background-sensitive syndactyly.
Polymorphisms RFLP(1) SNPs within 2kb(27 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process anterior/posterior pattern formation, apoptosis...
Component extracellular region
Function protein binding, Wnt-protein binding...
External Resources: FuncBase
Expression Literature Summary: (61 records)
Data Summary: Assays (11)    Results (60)    Tissues (38)    Images (56)
Theiler Stages: 5,8,9,11,13,15,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   7
      RNA in situ 8   51
      Northern blot 1   2
cDNA source data(51)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(61) cDNA(52) Primer pair(3) Other(6)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000027996
DoTS DT.101160312, DT.111066781, DT.55100405, DT.91401783
Consensus CDS Project CCDS17434.1
UniGene 19155
DFCI TC1575182
NIA Mouse Gene Index U003371
Entrez Gene 20319
VEGA Gene Model OTTMUSG00000021261
International Mouse Knockout Project Status Sfrp2
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR001134 Netrin domain
IPR008993 TIMP-like, OB-fold
IPR015526 Frizzled related
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:36732 Shirozu M et al., "Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method." Genomics 1996 Nov 1;37(3):273-80
(Latest) J:155074 Agalliu D et al., "Motor neurons with axial muscle projections specified by Wnt4/5 signaling." Neuron 2009 Mar 12;61(5):708-20
All references(76)
Other
accession IDs 		MGD-MRK-37115, MGI:2139824
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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