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Wnt10b Gene Detail
 Symbol
Name
ID
Wnt10b
wingless related MMTV integration site 10b
MGI:108061


Nomenclature History
Synonyms Wnt12
Genetic Map
Chromosome 15
56.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr15:98602193-98608581 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt10b ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic 22410 NCBI Gene Model | MGI Sequence Detail 6389 C57BL/6J ± Kb
transcript NM_011718 RefSeq | MGI Sequence Detail 2215 -
polypeptide P48614 UniProt | EBI | MGI Sequence Detail 389 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes
All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)
Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(14 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(13)
Process cell-cell signaling, multicellular organismal development...
Component extracellular region, proteinaceous extracellular matrix...
Function receptor binding, signal transducer activity...
External Resources: MouseFunc
Expression Literature Summary: (64 records)
Data Summary: Assays (26)    Results (260)    Tissues (210)    Images (47)
Theiler Stages: 1,2,3,4,5,8,9,11,13,15,17,18,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 9   36
      RNA in situ 8   141
      Immunohistochemistry 1   5
      Northern blot 6   72
      RNase protection 2   6
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(39) Genomic(4) cDNA(20) Primer pair(11) Other(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022996
DoTS DT.101340062, DT.55140088, DT.87039266, DT.87050049
UniGene 4709
DFCI TC1589662, TC1624423
NIA Mouse Gene Index U036631
Entrez Gene 22410
International Mouse Knockout Project Status Wnt10b
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR013302 Wnt-10 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:21464 Adamson MC et al., "Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a." Genomics 1994 Nov 1;24(1):9-13
(Latest) J:153785 Warner DR et al., "Expression of Wnts in the developing murine secondary palate." Int J Dev Biol 2009;53(7):1105-12
All references(80)
Other
accession IDs
MGD-MRK-18790, MGD-MRK-37098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory