Symbol
Name
ID
|
|
|
Synonyms
|
1110055K06Rik, Rock-I
|
|
Genetic Map
|
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Chromosome 18
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cytoband A2
|
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Mapping data(
3)
|
|
|
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Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(34)
|
Alleles
and
phenotypes
|
All alleles(9) :
Targeted, knock-out(1)
Targeted, other(2)
Gene trapped(6)
| Homozygous null mice have open eyes at birth, omphalocele, and most die soon after birth as a result of cannibalization by the mom. Survivors develop inflammation of the eyelid. Another homozygous mutant shows partial lethality around implantation and reduced cardiac fibrosis after pressure overload |
Phenotype Images (5)
|
|
Polymorphisms
|
SNPs within 2kb(329 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (15 records)
Data Summary:
Assays (5)
Results (20)
Tissues (13)
Images (10)
Theiler Stages: 11,13,15,17,18,19,21,26
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
2 |
|
4 |
| |
RT-PCR |
1 |
|
3 |
| |
RNA in situ |
2 |
|
13 |
cDNA source data(174)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(175)
cDNA(174)
Primer pair(1)
Antibodies(2)
Microarray probesets(5)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000861 |
HR1-like rho-binding repeat |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR001849 |
Pleckstrin homology |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR011009 |
Protein kinase-like domain |
| IPR015008 |
Rho Binding |
| IPR015751 |
Rho-associated coiled-coil containing protein kinase |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR020684 |
Rho-associated coiled-coil containing protein kinase-like |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:35061
Nakagawa O et al.,
"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice."
FEBS Lett 1996 Aug 26;392(2):189-93
(Latest)
J:149751
Lee DH et al.,
"Targeted disruption of ROCK1 causes insulin resistance in vivo."
J Biol Chem 2009 May 1;284(18):11776-80
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All references(41)
|
Other
accession IDs
|
MGD-MRK-36507, MGI:1916035
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Analysis Tools
MGI BioMart