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Ifng Gene Detail
 Symbol
Name
ID
Ifng
interferon gamma
MGI:107656


Nomenclature History
STS D10Mit24
Synonyms Ifg, IFN-gamma
Genetic Map
Chromosome 10
67.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 47)

Sequence Map
Chr10:117878103-117882948 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; goat; pig, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Ifng ± 2 cM)
Protein SuperFamily: interferon gamma
TreeFam: TF336308
Sequences
Representative Sequences Length Strain/Species Flank
genomic 15978 NCBI Gene Model | MGI Sequence Detail 4846 C57BL/6J ± Kb
transcript NM_008337 RefSeq | MGI Sequence Detail 1207 C57BL/6
polypeptide P01580 UniProt | EBI | MGI Sequence Detail 155 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(5) : Targeted, knock-out(2) Targeted, other(3)
Mutants show immune system abnormalities including decreased inflammatory response in one line, and uncontrolled splenocyte proliferation and susceptibility to intracellular pathogens in another.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms All PCR and RFLP(9) : PCR(1) RFLP(8) SNPs within 2kb(29 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(31)
Process antigen processing and presentation, defense response to bacterium...
Component extracellular region, extracellular space...
Function cytokine activity, interferon-gamma receptor binding...
External Resources: MouseFunc
Expression Literature Summary: (12 records)
Data Summary: Assays (6)    Results (82)    Tissues (45)    Images (3)
Theiler Stages: 16,18,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 5   79
      Northern blot 1   3
cDNA source data(11)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(20) cDNA(12) Primer pair(5) Other(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000055170
DoTS DT.101210515
UniGene 240327
DFCI TC1582456
NIA Mouse Gene Index U012054
Entrez Gene 15978
International Mouse Knockout Project Status Ifng
Protein
domains
InterPro ID Description
IPR002069 Interferon gamma
IPR009079 Four-helical cytokine-like, core
Graphical View of Protein Domain Structure
References
(Earliest) J:19935 Gray PW et al., "Cloning and expression of murine immune interferon cDNA." Proc Natl Acad Sci U S A 1983 Oct;80(19):5842-6
(Latest) J:154201 Poovassery J et al., "Association of malaria-induced murine pregnancy failure with robust peripheral and placental cytokine responses." Infect Immun 2009 Nov;77(11):4998-5006
All references(1008)
Other
accession IDs
MGD-MRK-11214, MGD-MRK-36231

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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