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Sox17 Gene Detail
 Symbol
Name
ID
Sox17
SRY-box containing gene 17
MGI:107543


Nomenclature History
Genetic Map
Chromosome 1
7.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr1:4481009-4486494 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sox17 ± 2 cM)
TreeFam: TF316183
Sequences
Representative Sequences Length Strain/Species Flank
genomic 20671 NCBI Gene Model | MGI Sequence Detail 5486 C57BL/6J ± Kb
transcript NM_011441 RefSeq | MGI Sequence Detail 3130 C57BL/6
polypeptide Q61473 UniProt | EBI | MGI Sequence Detail 419 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(1) Targeted, other(5)
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
Polymorphisms RFLP(1) SNPs within 2kb(37 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process angiogenesis, embryonic heart tube development...
Component nucleus
Function DNA binding, promoter binding...
External Resources: FuncBase
Expression Literature Summary: (25 records)
Data Summary: Assays (7)    Results (73)    Tissues (35)    Images (27)
Theiler Stages: 2,3,4,5,8,9,10,11,12,13,20,23,26,28
  Assay Type Assays   Results
      Western blot 1   8
      RT-PCR 2   18
      RNA in situ 3   41
      Immunohistochemistry 1   6
cDNA source data(33)
External Resources: GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(38) Genomic(1) cDNA(33) Primer pair(2) Other(2) Antibodies(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025902
DoTS DT.101364157, DT.101364158, DT.55277405, DT.91430997, DT.91580604
Consensus CDS Project CCDS14805.1
UniGene 279103
PDB 3F27
DFCI TC1582235, TC1595152, TC1595463, TC1601513, TC1612276
NIA Mouse Gene Index U021094
Entrez Gene 20671
International Mouse Knockout Project Status Sox17
Protein
domains
InterPro ID Description
IPR000910 High mobility group, HMG1/HMG2
IPR009071 High mobility group, superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:33784 Kanai Y et al., "Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis." J Cell Biol 1996 May;133(3):667-81
(Latest) J:155991 Engert S et al., "Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells." Genesis 2009 Sep;47(9):603-10
All references(37)
Other
accession IDs
MGD-MRK-36114

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
Web browser compatibility
The Jackson Laboratory