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Plcb4 Gene Detail
 Symbol
Name
ID
Plcb4
phospholipase C, beta 4
MGI:107464

Nomenclature History
Synonyms A930039J07Rik, C230058B11Rik
Genetic Map
Chromosome 2
77.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr2:135484747-135840329 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Plcb4 ± 2 cM)
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
TreeFam: TF313216
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000015959 VEGA Gene Model | MGI Sequence Detail 355583 C57BL/6J ± Kb
transcript NM_013829 RefSeq | MGI Sequence Detail 3692 C57BL/6
polypeptide NP_038857 RefSeq | MGI Sequence Detail 1175 C57BL/6
For the selected sequences
All sequences(47)
Alleles
and
phenotypes 		All alleles(72) : Targeted, knock-out(3) Gene trapped(69)
Homozygotes for targeted mutations may exhibit ataxia, impaired elimination of excess climbing fiber synapses in the developing cerebellum, abnormal cerebellar foliation, reduced visual processing ability and loss of circadian rhythm in constant darkness.
Phenotype Images (1)  
Polymorphisms RFLP(2) SNPs within 2kb(1581 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process signal transduction
Component dendrite, microsome...
Function protein binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (1)    Results (93)    Tissues (93)    Images (15)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   93
cDNA source data(62)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(67) Genomic(1) cDNA(64) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000039943
DoTS DT.101370775, DT.101735851, DT.103566167, DT.488760, DT.87025407, DT.91289211, DT.91304823, DT.91334166, DT.91422355
Consensus CDS Project CCDS16788.1
UniGene 38009
DFCI TC1595369, TC1598899, TC1600969, TC1603214, TC1611691, TC1612196, TC1619529, TC1622059
NIA Mouse Gene Index U002527
Entrez Gene 18798
VEGA Gene Model OTTMUSG00000015959
International Mouse Knockout Project Status Plcb4
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phospholipase C, phosphoinositol-specific, C-terminal (PLC)
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR009535 Protein of unknown function DUF1154
IPR011992 EF-hand-like domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR018029 C2 membrane targeting protein
References
(Earliest) J:30483 Hempel WM et al., "Expression of phospholipase C isozymes by murine B lymphocytes." J Immunol 1991 Jun 1;146(11):3713-20
(Latest) J:155425 Ikeda M et al., "Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice." PLoS One 2009;4(11):e7737
All references(34)
Other
accession IDs 		MGD-MRK-35936, MGI:1925078, MGI:2139106, MGI:2443533
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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