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Ppp3r1 Gene Detail
 Symbol
Name
ID
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
MGI:107172

Nomenclature History
Synonyms Cnb1, PP2B beta 1
Genetic Map
Chromosome 11
cytoband A3.1
 
Mapping data( 3)
Sequence Map
Chr11:17059266-17100378 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: calmodulin
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005195 VEGA Gene Model | MGI Sequence Detail 41113 C57BL/6J ± Kb
transcript NM_024459 RefSeq | MGI Sequence Detail 2829 C57BL/6
polypeptide Q63810 UniProt | EBI | MGI Sequence Detail 170 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes 		All alleles(7) : Targeted, knock-out(1) Targeted, other(3) Gene trapped(3)
Homozygous inactivation of this gene results in embryonic death by midgestation due to vascular patterning defects.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(131 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process epithelial to mesenchymal transition, heart development...
Function calcium ion binding
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (1)    Results (2)    Tissues (2)    Images (1)
Theiler Stages: 21,24
  Assay Type Assays   Results
      RT-PCR 1   2
cDNA source data(126)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(129) Genomic(2) cDNA(126) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033953
DoTS DT.101363045, DT.55162242, DT.91333886, DT.97344694
Consensus CDS Project CCDS24448.1
UniGene 41840
DFCI TC1593143, TC1606700, TC1659508
Entrez Gene 19058
VEGA Gene Model OTTMUSG00000005195
International Mouse Knockout Project Status Ppp3r1
Protein
domains
InterPro ID Description
IPR001680 WD40 repeat
IPR002048 Calcium-binding EF-hand
IPR008080 Parvalbumin
IPR011046 WD40 repeat-like-containing domain
IPR011992 EF-hand-like domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR017986 WD40-repeat-containing domain
IPR018247 EF-Hand 1, calcium-binding site
IPR018248 EF-Hand domain
IPR018249 EF-HAND 2
IPR019781 WD40 repeat, subgroup
IPR019782 WD40 repeat 2
Graphical View of Protein Domain Structure
References
(Earliest) J:2181 Ueki K et al., "Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B)." Biochem Biophys Res Commun 1992 Aug 31;187(1):537-43
(Latest) J:154803 Choo MK et al., "NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation." Bone 2009 Sep;45(3):579-89
All references(30)
Other
accession IDs 		MGD-MRK-35633
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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