Symbol
Name
ID
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Synonyms
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1110063J16Rik, Calnb, CnAbeta, PP2BA beta
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Genetic Map
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Chromosome 14
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cytoband B
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Mapping data(
3)
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(28)
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Alleles
and
phenotypes
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All alleles(19) :
Targeted, knock-out(1)
Gene trapped(18)
| Homozygous null mice have small hearts and thymi, and reduced body weight. Cardiac function is normal, but mice lack a cardiac hypertrophic response to pressure overload, angiotensin II, or isopreteronol. Thymi are hypoplastic, with abnormal T cell development and reduced numbers of T cells. |
Phenotype Images (1)
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Polymorphisms
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SNPs within 2kb(133 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (2 records)
Data Summary:
Assays (1)
Results (2)
Tissues (2)
Images (1)
Theiler Stages: 21,24
| |
Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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2 |
cDNA source data(12)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(13)
cDNA(12)
Primer pair(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR004843 |
Metallophosphoesterase |
| IPR006186 |
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
Graphical View
of Protein Domain Structure
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|
References
|
(Earliest)
J:368
Giri PR et al.,
"Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit."
Biochem Biophys Res Commun 1991 Nov 27;181(1):252-8
(Latest)
J:156429
Donaldson C et al.,
"Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation."
Circ Res 2009 Jan 30;104(2):265-75, 11p following 275
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All references(31)
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Other
accession IDs
|
MGD-MRK-1737, MGD-MRK-35624, MGI:1913465
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Analysis Tools
MGI BioMart