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Dvl2 Gene Detail
 Symbol
Name
ID
Dvl2
dishevelled 2, dsh homolog (Drosophila)
MGI:106613


Nomenclature History
Genetic Map
Chromosome 11
36.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr11:69814097-69825803 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Dvl2 ± 2 cM)
Protein SuperFamily: segment polarity protein dishevelled homolog DVL
TreeFam: TF318198
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000006016 VEGA Gene Model | MGI Sequence Detail 11707 C57BL/6J ± Kb
transcript NM_007888 RefSeq | MGI Sequence Detail 2937 C57BL/6
polypeptide Q60838 UniProt | EBI | MGI Sequence Detail 736 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes
All alleles(7) : Targeted, knock-out(1) Gene trapped(6)
Homozygous mice show incomplete penetrance of perinatal lethality with surviving mice being predominantly female. Defects include cardiovascular outflow and neural tube abnormalities, malformations of vertebrae and ribs, and irregular somite segmentation.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(73 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process heart development, intracellular signaling cascade...
Component cytoplasm, cytoskeleton...
Function protein binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (15 records)
Data Summary: Assays (4)    Results (81)    Tissues (65)    Images (15)
Theiler Stages: 1,2,3,4,5,20,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   63
      RNA in situ 1   13
      Immunohistochemistry 1   5
cDNA source data(80)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(87) Genomic(3) cDNA(81) Primer pair(3) Antibodies(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020888
DoTS DT.110532258, DT.492472, DT.94273101
Consensus CDS Project CCDS24930.1
UniGene 5114
DFCI TC1574779
NIA Mouse Gene Index U108773
Entrez Gene 13543
VEGA Gene Model OTTMUSG00000006016
International Mouse Knockout Project Status Dvl2
Protein
domains
InterPro ID Description
IPR000591 DEP domain
IPR001158 DIX
IPR001478 PDZ/DHR/GLGF
IPR003351 Dishevelled protein
IPR008339 Dishevelled region
IPR008341 Dishevelled-2 region
IPR011991 Winged helix repressor DNA-binding
IPR015506 Dishevelled related protein
Graphical View of Protein Domain Structure
References
(Earliest) J:33550 Greco TL et al., "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11." Mamm Genome 1996 Jun;7(6):475-6
(Latest) J:153468 Bouteille N et al., "Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein." Oncogene 2009 Jul 16;28(28):2569-80
All references(35)
Other
accession IDs
MGD-MRK-35070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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