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Cdc42 Gene Detail
 Symbol
Name
ID
Cdc42
cell division cycle 42 homolog (S. cerevisiae)
MGI:106211

Nomenclature History
Genetic Map
Chromosome 4
66.75 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr4:136875611-136913635 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cdc42 ± 2 cM)
Protein SuperFamily: small GTPase, Rho type
TreeFam: TF101109
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009829 VEGA Gene Model | MGI Sequence Detail 38025 C57BL/6J ± Kb
transcript NM_009861 RefSeq | MGI Sequence Detail 2129 C57BL/6
polypeptide P60766 UniProt | EBI | MGI Sequence Detail 191 Not Applicable
For the selected sequences
All sequences(57)
Alleles
and
phenotypes 		All alleles(71) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(68)
Polymorphisms SNPs within 2kb(157 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process adherens junction organization, cell division...
Component apical part of cell, cell projection...
Function GTP binding, GTP-dependent protein binding...
External Resources: FuncBase
Expression Literature Summary: (30 records)
Data Summary: Assays (12)    Results (89)    Tissues (71)    Images (20)
Theiler Stages: 2,3,4,5,15,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 7   17
      RT-PCR 2   58
      RNA in situ 1   6
      Immunohistochemistry 2   8
cDNA source data(48)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(53) Genomic(2) cDNA(48) Primer pair(3) Antibodies(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000006699
Consensus CDS Project CCDS18816.1
PDB 3EG5
NIA Mouse Gene Index U025678, U112227
Entrez Gene 12540
VEGA Gene Model OTTMUSG00000009829
International Mouse Knockout Project Status Cdc42
Protein
domains
InterPro ID Description
IPR001806 Ras GTPase
IPR003578 Small GTPase, Rho type
IPR005225 Small GTP-binding protein
IPR013753 Ras
Graphical View of Protein Domain Structure
References
(Earliest) J:5848 Johnson DR, "Ultrastructural observations on stumpy (stm), a new chondrodystrophic mutant in the mouse." J Embryol Exp Morphol 1977 Jun;39():279-84
(Latest) J:154928 Szczur K et al., "The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling." Blood 2009 Nov 12;114(20):4527-37
All references(102)
Other
accession IDs 		MGD-MRK-33903, MGI:2140354, MGI:2140443
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory