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Hsd17b4 Gene Detail
 Symbol
Name
ID
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
MGI:105089

Nomenclature History
Synonyms 17[b]-HSD, D-bifunctional protein, MFE-2, Mfp-2, MFP2, multifunctional protein 2, perMFE-2
Genetic Map
Chromosome 18
45.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 2)

Sequence Map
Chr18:50287855-50355923 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Hsd17b4 ± 2 cM)
TreeFam: TF105656
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021126 VEGA Gene Model | MGI Sequence Detail 68069 C57BL/6J ± Kb
transcript NM_008292 RefSeq | MGI Sequence Detail 2612 FVB/N
polypeptide P51660 UniProt | EBI | MGI Sequence Detail 735 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(1) Gene trapped(5)
Mice homozygous for disruptions in this gene have abnormalities infatty acid metabolism. The mice have retarded growth and abnormal bile salt composition.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (3)  
Polymorphisms SNPs within 2kb(340 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process...
Component mitochondrion, peroxisome...
Function 3-hydroxyacyl-CoA dehydrogenase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (2)    Results (30)    Tissues (9)
Theiler Stages: 15,19,22,26,28
  Assay Type Assays   Results
      Western blot 1   15
      Northern blot 1   15
cDNA source data(15)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(15) cDNA(15) Antibodies(1)
Microarray probesets(2)
Pathways
fatty acid β-oxidation I
fatty acid β-oxidation II (core pathway)
Other database
links
EC 1.1.1.35, 4.2.1.107
Ensembl Gene Model ENSMUSG00000024507
DoTS DT.534544
Consensus CDS Project CCDS29242.1
DFCI TC1573583
NIA Mouse Gene Index U018718
Entrez Gene 15488
VEGA Gene Model OTTMUSG00000021126
International Mouse Knockout Project Status Hsd17b4
Protein
domains
InterPro ID Description
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002539 MaoC-like dehydratase
IPR003033 Sterol-binding
IPR016040 NAD(P)-binding domain
IPR016083 Sterol-binding-like
IPR020904 Short-chain dehydrogenase/reductase, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:30644 Normand T et al., "Molecular characterization of mouse 17 beta-hydroxysteroid dehydrogenase IV." J Steroid Biochem Mol Biol 1995 Dec;55(5-6):541-8
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(26)
Other
accession IDs 		MGD-MRK-32129, MGI:2147354
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory