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Ahr Gene Detail
 Symbol
Name
ID
Ahr
aryl-hydrocarbon receptor
MGI:105043


Nomenclature History
Synonyms Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
Genetic Map
Chromosome 12
18.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 36)

Sequence Map
Chr12:36182651-36219661 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rabbit, European; rat; hamster, golden    (Mammalian Orthology)
Comparative Map (Mouse/Human Ahr ± 2 cM)
TreeFam: TF317772
Sequences
Representative Sequences Length Strain/Species Flank
genomic 11622 NCBI Gene Model | MGI Sequence Detail 37011 C57BL/6J ± Kb
transcript NM_013464 RefSeq | MGI Sequence Detail 5494 C57BL/6
polypeptide Q8R4S5 UniProt | EBI | MGI Sequence Detail 883 Not Applicable
For the selected sequences
All sequences(74)
Alleles
and
phenotypes
All alleles(12) : Targeted, knock-out(2) Targeted, other(6) Other(4)
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities.
Phenotype Images (1)  
Polymorphisms PCR(1) SNPs within 2kb(349 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(22)
Process cell cycle, gland development...
Component cytoplasm, nucleus...
Function DNA binding, receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (12 records)
Data Summary: Assays (6)    Results (96)    Tissues (55)    Images (6)
Theiler Stages: 2,3,4,5,16,17,20,21,22,28
  Assay Type Assays   Results
      RT-PCR 3   32
      RNA in situ 3   64
cDNA source data(66)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(80) Genomic(10) cDNA(66) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019256
DoTS DT.101125370, DT.101135033, DT.101353216, DT.94402283
UniGene 341377
DFCI TC1602896, TC1618782, TC1740581
NIA Mouse Gene Index U013861
Entrez Gene 11622
International Mouse Knockout Project Status Ahr
Protein
domains
InterPro ID Description
IPR000014 PAS
IPR001092 Helix-loop-helix DNA-binding domain
IPR001610 PAC motif
IPR013655 PAS fold-3
IPR013767 PAS fold
Graphical View of Protein Domain Structure
References
(Earliest) J:84245 Poel WE et al., "Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene" Proc Am Assoc Cancer Res 1958;2():335
(Latest) J:154083 Yeager RL et al., "Introducing the 'TCDD-inducible AhR-Nrf2 gene battery'." Toxicol Sci 2009 Oct;111(2):238-46
All references(248)
Other
accession IDs
MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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