Symbol
Name
ID
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Synonyms
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Leprb, LEPROT, leptin receptor gene-related protein, Modb1, OB-RGRP, obese-like, obl, Obr
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(76)
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Alleles
and
phenotypes
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All alleles(30) :
Targeted, knock-out(2)
Targeted, other(9)
Transgenic(1)
Spontaneous(13)
Chemically induced(5)
| Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion. They are obese, hyperinsulinemic and, on certain strains, severely hyperglycemic. Heterozygotes are normal but resistant to prolonged fasting. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (14)
Phenotype Images (4)
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Polymorphisms
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All PCR and RFLP(3) :
PCR(2)
RFLP(1)
SNPs within 2kb(376 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (13 records)
Data Summary:
Assays (8)
Results (84)
Tissues (61)
Images (1)
Theiler Stages: 10,13,15,17,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
5 |
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70 |
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RNA in situ |
1 |
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2 |
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Northern blot |
2 |
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12 |
cDNA source data(24)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(55)
Genomic(25)
cDNA(24)
Primer pair(5)
Other(1)
Microarray probesets(4)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000057722 |
| DoTS |
DT.101348334, DT.101368835, DT.101368836, DT.110827087, DT.482434, DT.526088, DT.60101619, DT.91337499, DT.94184061 |
| DFCI |
TC1582480, TC1586489, TC1590522, TC1641716 |
| NIA Mouse Gene Index |
U004553 |
| Entrez Gene |
16847 |
| VEGA Gene Model |
OTTMUSG00000008454 |
| International Mouse Knockout Project Status |
Lepr |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR003529 |
Long hematopoietin receptor, gp130 family 2, conserved site |
| IPR003531 |
Short hematopoietin receptor, family 1, conserved site |
| IPR003961 |
Fibronectin, type III |
| IPR007110 |
Immunoglobulin-like |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR010457 |
Immunoglobulin C2-set-like, ligand-binding |
| IPR015752 |
Leptin receptor |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:31691
Falconer DS et al.,
"Adipose, a new inherited obesity of the mouse"
J Hered 1959;50():290-292
(Latest)
J:153493
Pietramaggiori G et al.,
"Improved cutaneous healing in diabetic mice exposed to healthy peripheral circulation."
J Invest Dermatol 2009 Sep;129(9):2265-74
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All references(598)
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Other
accession IDs
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MGD-MRK-12969, MGD-MRK-31066, MGD-MRK-8799
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