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Pdcd1 Gene Detail
 Symbol
Name
ID
Pdcd1
programmed cell death 1
MGI:104879

Nomenclature History
Synonyms PD-1, Pdc1
Genetic Map
Chromosome 1
Syntenic
 
Mapping data( 3)
Sequence Map
Chr1:95934884-95949130 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF336181
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000026285 Ensembl Gene Model | MGI Sequence Detail 14247 C57BL/6J ± Kb
transcript NM_008798 RefSeq | MGI Sequence Detail 1972 -
polypeptide Q02242 UniProt | EBI | MGI Sequence Detail 288 Not Applicable
For the selected sequences
All sequences(13)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(2) Targeted, other(1)
Mice homozygous for disruptions in this gene display abnormalities in leukopoiesis and the immune system which vary considerably depending on the genetic background.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(65 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process apoptosis
Component external side of plasma membrane, integral to membrane...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(4)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(4) cDNA(4)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000026285
DoTS DT.55131714
Consensus CDS Project CCDS15200.1
UniGene 5024
PDB 1NPU, 3BIK, 3BP5, 3BP6
DFCI TC1589965
NIA Mouse Gene Index U021620
Entrez Gene 18566
International Mouse Knockout Project Status Pdcd1
Protein
domains
InterPro ID Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR013106 Immunoglobulin V-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:35861 Ishida Y et al., "Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death." EMBO J 1992 Nov;11(11):3887-95
(Latest) J:154573 Sugita S et al., "T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions." Invest Ophthalmol Vis Sci 2009 Jun;50(6):2862-70
All references(65)
Other
accession IDs 		MGD-MRK-13206, MGD-MRK-29032
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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