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Akt2 Gene Detail
 Symbol
Name
ID
Akt2
thymoma viral proto-oncogene 2
MGI:104874

Nomenclature History
Synonyms 2410016A19Rik, PKB, PKBbeta
Genetic Map
Chromosome 7
6.5 cM, cytoband B1
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr7:28376571-28425845 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Akt2 ± 2 cM)
Protein SuperFamily: RAC serine/threonine-protein kinase
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016504 VEGA Gene Model | MGI Sequence Detail 49275 C57BL/6J ± Kb
transcript NM_001110208 RefSeq | MGI Sequence Detail 3199 C57BL/6
polypeptide Q60823 UniProt | EBI | MGI Sequence Detail 481 Not Applicable
For the selected sequences
All sequences(43)
Alleles
and
phenotypes 		All alleles(43) : Targeted, knock-out(3) Targeted, other(3) Gene trapped(37)
Homozygotes for targeted null mutations exhibit insulin resistance and elevated plasma triglycerides. In males, the insulin resistance may progress to overt diabetes.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(2) SNPs within 2kb(192 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to insulin stimulus, positive regulation of sodium ion transport...
Component lamellipodium
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (15 records)
Data Summary: Assays (1)    Results (11)    Tissues (11)
Theiler Stages: 28
  Assay Type Assays   Results
      Western blot 1   11
cDNA source data(131)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(134) Genomic(1) cDNA(132) Primer pair(1) Antibodies(2)
Microarray probesets(4)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000004056
DoTS DT.110506073, DT.494578, DT.97340787, DT.99861796
Consensus CDS Project CCDS21027.1
UniGene 177194
DFCI TC1586401, TC1627096, TC1646907, TC1718092, TC1781932
NIA Mouse Gene Index U007859, U028304
Entrez Gene 11652
VEGA Gene Model OTTMUSG00000016504
International Mouse Knockout Project Status Akt2
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR001849 Pleckstrin homology
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR011993 Pleckstrin homology-type
IPR015744 Rac serine/threonine kinase
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:32638 Staal SP, "Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma." Proc Natl Acad Sci U S A 1987 Jul;84(14):5034-7
(Latest) J:156391 Buzzi F et al., "Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass." Mol Cell Biol 2010 Feb;30(3):601-12
All references(66)
Other
accession IDs 		MGD-MRK-28173, MGI:1923730, MGI:2142261
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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