Symbol
Name
ID
|
|
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Synonyms
|
DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha
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Genetic Map
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(50)
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Alleles
and
phenotypes
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All alleles(20) :
Targeted, knock-out(13)
Targeted, other(4)
Spontaneous(2)
Chemically induced(1)
| Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
Phenotype Images (1)
|
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Polymorphisms
|
All PCR and RFLP(22) :
PCR(10)
RFLP(12)
SNPs within 2kb(31 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
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Expression
|
Literature Summary: (38 records)
Data Summary:
Assays (10)
Results (185)
Tissues (86)
Images (4)
Theiler Stages: 13,16,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
9 |
|
176 |
| |
Northern blot |
1 |
|
9 |
cDNA source data(19)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(94)
Genomic(53)
cDNA(20)
Primer pair(14)
Other(7)
Microarray probesets(2)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR002959 |
Tumour necrosis factor alpha/cachectin |
| IPR006052 |
Tumor Necrosis Factor |
| IPR006053 |
Tumor necrosis factor alpha/beta/c |
| IPR008983 |
Tumour necrosis factor-like |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:7045
Rinchik EM et al.,
"Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2."
Immunogenetics 1983;17(5):445-55
(Latest)
J:154204
Muller S et al.,
"Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death."
Eur J Immunol 2009 Aug 13;39(11):3171-3180
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All references(909)
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Other
accession IDs
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MGD-MRK-15151, MGD-MRK-28090
|
