Symbol
Name
ID
|
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
MGI:104741
|
Nomenclature History
|
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Synonyms
|
I(Kappa)B(alpha), I-kappaBalpha, IkappaBalpha, Nfkbi
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Genetic Map
|
|
Chromosome 12
|
cytoband C1-C3
|
|
|
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Mapping data(
4)
|
|
|
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Sequence Map
|
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Mammalian
homology
|
|
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Sequences
|
All sequences(24)
|
Alleles
and
phenotypes
|
All alleles(7) :
Targeted, knock-out(3)
Targeted, other(3)
Gene trapped(1)
| Mice homozygous for disruptions in this gene die at about 1 week of age experiencing abnormalities in the immune system. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
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Polymorphisms
|
SNPs within 2kb(16 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (14 records)
Data Summary:
Assays (4)
Results (57)
Tissues (47)
Images (4)
Theiler Stages: 2,3,4,5,17,18,21,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
9 |
| |
RT-PCR |
1 |
|
15 |
| |
RNA in situ |
2 |
|
33 |
cDNA source data(114)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(118)
Genomic(3)
cDNA(114)
Primer pair(1)
Antibodies(1)
Microarray probesets(5)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:2281
Kawaichi M et al.,
"Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene."
J Biol Chem 1992 Feb 25;267(6):4016-22
(Latest)
J:147968
Liu M et al.,
"Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo."
Am J Pathol 2009 May;174(5):1910-20
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All references(82)
|
Other
accession IDs
|
MGD-MRK-12830, MGD-MRK-28032, MGI:2144835
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Analysis Tools
MGI BioMart