Symbol
Name
ID
|
|
|
Synonyms
|
alpha3(IV), tumstatin
|
|
Genetic Map
|
|
Chromosome 1
|
Syntenic
|
|
|
|
Mapping data(
3)
|
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(14)
|
Alleles
and
phenotypes
|
All alleles(2) :
Targeted, knock-out(2)
| Homozygotes for targeted null mutations exhibit renal pathology including reduced glomerular filtration, impaired glomerular integrity, and glomerulonephrosis, resulting in uremia, proteinuria, and high mortality in young adults. Auditory thresholds are mildly increased across all test frequencies. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (2)
Phenotype Images (2)
|
|
Polymorphisms
|
SNPs within 2kb(740 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (5)
Results (31)
Tissues (28)
Images (5)
Theiler Stages: 15,17,21,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
6 |
| |
RNA in situ |
1 |
|
20 |
| |
Immunohistochemistry |
2 |
|
5 |
cDNA source data(13)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(17)
Genomic(1)
cDNA(14)
Primer pair(2)
Antibodies(2)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001442 |
Collagen IV, non-collagenous |
| IPR008160 |
Collagen triple helix repeat |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:21122
Miner JH et al.,
"Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches."
J Cell Biol 1994 Nov;127(3):879-91
(Latest)
J:150527
Bai X et al.,
"Developmental distribution of collagen IV isoforms and relevance to ocular diseases."
Matrix Biol 2009 May;28(4):194-201
|
All references(46)
|
Other
accession IDs
|
MGD-MRK-27051
|
