Symbol
Name
ID
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(19)
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Alleles
and
phenotypes
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All alleles(3) :
Targeted, other(1)
Spontaneous(2)
| Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan. Strain background greatly affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice. |
Associated Human Diseases (3)
Alleles Annotated to Human Diseases (1)
Phenotype Images (2)
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Polymorphisms
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All PCR and RFLP(5) :
PCR(4)
RFLP(1)
SNPs within 2kb(138 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (10 records)
Data Summary:
Assays (8)
Results (63)
Tissues (48)
Images (3)
Theiler Stages: 23,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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46 |
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Northern blot |
7 |
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17 |
cDNA source data(29)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(49)
Genomic(12)
cDNA(32)
Primer pair(5)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000065 |
Obesity factor |
| IPR009079 |
Four-helical cytokine-like, core |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:13066
INGALLS AM et al.,
"Obese, a new mutation in the house mouse."
J Hered 1950 Dec;41(12):317-8
(Latest)
J:153762
Li X et al.,
"Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice."
FEBS Lett 2009 Oct 6;583(19):3230-4
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All references(747)
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Other
accession IDs
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MGD-MRK-12967, MGD-MRK-26103
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