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Mcf2l Gene Detail
 Symbol
Name
ID
Mcf2l
mcf.2 transforming sequence-like
MGI:103263


Nomenclature History
Synonyms C130040G20Rik, Dbs, mKIAA0362
Genetic Map
Chromosome 8
cytoband A2
 
Mapping data( 2)
Sequence Map
Chr8:12873806-13020527 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: dbl transforming protein
TreeFam: TF318080
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000020608 VEGA Gene Model | MGI Sequence Detail 146722 C57BL/6J ± Kb
transcript NM_178076 RefSeq | MGI Sequence Detail 5269 C57BL/6
polypeptide Q64096 UniProt | EBI | MGI Sequence Detail 1149 Not Applicable
For the selected sequences
All sequences(56)
Alleles
and
phenotypes
All alleles(11) : Gene trapped(11)
Polymorphisms SNPs within 2kb(1007 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(13)
Process intracellular signaling cascade, regulation of Rho protein signal transduction...
Component cytoplasm, intracellular...
Function guanyl-nucleotide exchange factor activity, phosphatidylinositol binding...
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (25)    Tissues (18)    Images (15)
Theiler Stages: 21,22,24,25,26,28
  Assay Type Assays   Results
      RNA in situ 2   19
      Northern blot 1   6
cDNA source data(128)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(129) cDNA(129)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000031442
DoTS DT.101217837, DT.101386398, DT.101386401, DT.101737809, DT.101737810, DT.110900679, DT.530388, DT.55244243, DT.94162731
UniGene 334413
PDB 1KZ7, 1KZG, 1LB1, 1RJ2
DFCI TC1574408, TC1594206, TC1604419, TC1609018, TC1609157, TC1617336, TC1695881
NIA Mouse Gene Index U009095
Entrez Gene 17207
VEGA Gene Model OTTMUSG00000020608
International Mouse Knockout Project Status Mcf2l
Protein
domains
InterPro ID Description
IPR000219 Dbl homology (DH) domain
IPR001251 Cellular retinaldehyde-binding/triple function, C-terminal
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001452 Src homology-3 domain
IPR001849 Pleckstrin homology
IPR002017 Spectrin repeat
IPR011993 Pleckstrin homology-type
IPR018159 Spectrin/alpha-actinin
Graphical View of Protein Domain Structure
References
(Earliest) J:23628 Whitehead I et al., "Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor." Oncogene 1995 Feb 16;10(4):713-21
(Latest) J:116538 Baumeister MA et al., "The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity." Biochem J 2006 Dec 15;400(3):563-72
All references(13)
Other
accession IDs
MGD-MRK-24142, MGI:2442384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory